Protein Details: Voltage-gated Potassium channel-interacting protein 4

Protein ID

ICDB_Pro_1098

Protein Name

Voltage-gated Potassium channel-interacting protein 4

Gene Name

KCNIP4; CALP; KCHIP4

Organism

Homo sapiens (Human)

Length

250 amino acids

AlphaFoldDB

AF-Q6PIL6-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density;inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane

Sequence

MNVRRVESISAQLEEASSTGGFLYAQNSTKRSIKERLMKLLPCSAAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

133;135;137;144;169;171;173;175;180;217;219;221;228

Disease

Transitional Meningioma

Location

Predominantly expressed in brain.

DOI ID

10.1074/jbc.m200897200; 10.1073/pnas.022509299; 10.1016/j.ygeno.2005.07.001; 10.1038/ng1285; 10.1038/nature03466; 10.1101/gr.2596504; 10.1074/jbc.m806852200; 10.1074/jbc.m111.301853; 10.1074/jbc.m113.466052; 10.1074/jbc.m114.563452

RefSeq

NP_001030175.1 [Q6PIL6-5]; NP_001030176.1 [Q6PIL6-3]; NP_079497.2 [Q6PIL6-1]; NP_671710.1 [Q6PIL6-2]; NP_671711.1 [Q6PIL6-3]; NP_671712.1 [Q6PIL6-4]; XP_016864142.1